August 4, 2015

'Summary Statistics from Meta-Analyses of Serum Urate and Gout'

Information about the posted Global Urate Genetics Consortium (GUGC) datasets

The two posted datasets described below contain the summary statistics underlying the findings described in “Genome-wide association analyses identify 18 new loci associated with serum urate concentrations”. Nat Genet. 2013 Feb;45(2):145-54. PMID: 23263486

1. GUGC_MetaAnalysis_Results_UA.csv

This file contains the summary statistics for association with serum urate concentrations from meta-analysis of up to 110,347 individuals from 48 studies. 
It has the following headers:
MarkerName: rs identifier of the SNP
n_total: number of individuals with available SNP information
A1: the modeled allele, i.e. the allele to which the beta estimate refers to
A2: the other allele
beta: effect of each additional copy of A1 on serum urate concentrations in mg/dl
se: standard error of the beta
p_gc: genomic control corrected p-value for association

2.  GUGC_MetaAnalysis_Results_Gout.csv

This file contains the summary statistics for association with gout from meta-analysis of up to 2,115 gout cases and 67,259 controls from 14 studies. 
It has the following headers:
MarkerName: rs identifier of the SNP
n_total: number of individuals with available SNP information
A1: the modeled allele, i.e. the allele to which the beta estimate refers to
A2: the other allele
beta: log odds of each additional copy of A1. To obtain the odds ratio for gout per allele, exponentiate the beta. OR = exp(beta)
se: standard error of the beta
p_gc: genomic control corrected p-value for association

Questions? 
Please contact
Anna Kottgen, anna.koettgen@uniklinik-freiburg.de
Christian Gieger, christian.gieger@helmholtz-muenchen.de