Nat Genet. 2017 Jun;49(6):834-841. doi: 10.1038/ng.3841. Epub 2017 Apr 24.
Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk.

Genome-wide array data, imputed to the 1000 Genomes Project reference panel, were available in up to 329,345 women of European ancestry. These comprised 40 studies from the ReproGen consortium (N = 179,117), in addition to the 23andMe (N = 76,831) and UK Biobank (N = 73,397) studies. Each individual study tested SNPs using a two-tailed additive linear regression model for association with AAM, including age at study visit and other study-specific covariates.

Results file obtained from: http://www.reprogen.org/Menarche_1KG_NatGen2017_WebsiteUpload.zip

Column descriptions:
Markername, SNP or variant ID; Allele1, major allele; Allele2, minor allele; Effect, effect size; Pvalue, p-value; Minor_Allele, specifies the minor effect allele.

This ReadMe was generated by NHLBI.