############################################################################### # # # Description : IGAP meta-analysis results files # # Publication : Meta-analysis of 74,046 individuals identifies 11 new # susceptibility loci for Alzheimer's disease. # # Reference : Nat Genet. 2013 Dec;45(12):1452-8. doi: 10.1038/ng.2802. # # Date : 2014-06-27 # # Author : IGAP consortium # # ############################################################################### ############################################################################### # # Filename : IGAP_stage_1.txt # # Description : Contains IGAP Stage 1 results of SNPs either genotyped or # successfully imputed in at least 40% of the AD cases and 40% # of the control samples across all datasets (7,055,881 SNPs) # # md5sum : bc89de2613f1c61537c7d1a8cff01b3d # sha1sum : 5efcb61fd33814ab62aa294d81186fdba80423b2 # ############################################################################### # Column name : Description #---------------:-------------------------------------------------------------- - Chromosome : Chromosome of the SNP (Build 37, Assembly Hg19) - Position : Position of the SNP (Build 37, Assembly Hg19) - MarkerName : SNP rsID or chromosome:position if rsID not available - Effect_allele : Reference allele (coded allele) - Other_allele : Non reference allele (non-coded allele) - Beta : Overall estimated effect size for the effect allele - SE : Overall standard error for effect size estimate - Pvalue : Meta-analysis Pvalue for stage 1 ############################################################################### # # Filename : IGAP_stage_1_2_combined.txt # # Description : Contains IGAP combined results for # 11,632 SNPs considered for analysis after quality control # procedures # # md5sum : 7618a9ea7539f4c3344e4812146da88e # sha1sum : bcd6e2e059d02ecdcc592f07e485eb2e00176581 # ############################################################################### # Column name : Description #-----------------------:------------------------------------------------------ - Chromosome : Chromosome of the SNP (Build 37, Assembly Hg19) - Position : Position of the SNP (Build 37, Assembly Hg19) - MarkerName : SNP rsID or chromosome:position if rsID not available - Effect_allele : Reference allele (coded allele) - Non_Effect_allele : Non reference allele (non-coded allele) - Beta : Overall estimated effect size for Effect allele in the combined stage 1 and stage 2 datasets - SE : Overall standard error for effect size estimate in the combined stage 1 and stage 2 datasets - Pvalue : Meta-analysis Pvalue for the combined stage 1 and stage 2